GnRH Increases c-Fos Half-Life Contributing to Higher FSHβ Induction
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چکیده
منابع مشابه
Induction of apoptosis by c-Fos protein.
The role of c-Fos in apoptosis was examined in two Syrian hamster embryo cell lines (sup+I and sup-II) and a human colorectal carcinoma cell line (RKO), using the chimeric Fos-estrogen receptor fusion protein c-FosER. As previously reported, contrasting responses were observed when these two cell lines were placed under growth factor deprivation conditions; sup+I cells were highly susceptible t...
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The induction of c-fos mRNA was assessed using Northern blots and in situ hybridization in adult rats administered hypertonic saline (HS) and isotonic saline (IS). HS induced c-fos mRNA in magnocellular paraventricular nucleus (PVNm), parvocellular paraventricular nucleus (PVNp), supraoptic nucleus (SON), and lamina terminalis (LMT). This occurred within 5 min, peaked at 30-60 min, and disappea...
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Insulin can stimulate the expression of c-fos and other immediate early genes in many insulin-sensitive cell types. We found previously that this effect of insulin was essentially normal in cells in which protein kinase C (PKC) was down-regulated by 16 h of exposure to 16 microM phorbol 12-myristate 13-acetate (PMA). However, recent studies by other groups have suggested that much of the insuli...
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Several studies have shown that altered gravity conditions influence mammalian cell growth and differentiation. The molecular mechanisms underlying these effects, however, remain relatively obscure. In this paper we show that microgravity reached in a sounding rocket strongly decreases epidermal growth factor (EGF)-induced expression of the proto-oncogenes c-fos and c-jun, which are both implic...
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We have compared the mechanisms of the transcriptional induction of c-fos in mouse epidermal cells JB6 (clone 30) by an extracellular burst of active oxygen of the type produced by inflammatory phagocytes to induction by serum and phorbol ester. All three inducers elicit a characteristic immediate early response of c-fos which is inhibited by the protein kinase inhibitor H7 but enhanced by the ...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2013
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2012-1168